Scientific Evidence for Conditions that Increase Risk of Severe Illness | COVID-19




Strongest and Most Consistent Evidence Cancer Systematic Review [6]
Cohort Study [7,8]
Case Series [9] New to updated list as of July 17, 2020 Chronic kidney disease Case Series [10, 11, 12]
Cohort Studies [13, 14, 15] On previous version of list as “Chronic Kidney Disease Requiring Dialysis” COPD Meta Analyses [4, 16]
Case Series [17]
Cohort Study [14] On previous version of list Heart conditions, such as heart failure, coronary artery disease, or cardiomyopathies Cohort Study [1, 2]
Meta Analyses [3, 4]
Case Series [5] On previous version of list as “Serious Heart Conditions” Obesity (BMI> 30 kg/m2) Cohort Studies [18, 19, 20, 21, 22]
Cross-sectional [23] On previous version of list as “Severe Obesity (BMI ≥40)” Severe Obesity (BMI ≥ 40 kg/m2) Cohort Study [98, 99]
Cross-Sectional Study [95]
Meta Analysis [107] Previously unlisted Sickle cell disease Case Series [24, 25, 26, 27, 28] On previous version of list Smoking Meta Analyses [3, 16*, 63, 64, 65, 66, 101, 102, 104, 105] On previous version of list Solid organ transplantation Case Series [12, 29, 30, 31, 32, 33, 34]
Meta Analysis [100] New to updated list as of June 25, 2020 Type 2 diabetes mellitus Case Series [11]
Longitudinal Study [35]
Cohort Study [36, 37]
Meta Analysis [38]
Cross-Sectional Study [114] On previous version of list Mixed Evidence Asthma Cohort Study [14, 39, 40, 41]
Case Series [17] On previous version of list Cerebrovascular disease Meta Analysis [42, 43, 44, 45]
Synthesis of Evidence [46]
Cohort Study [1, 2, 47, 48, 49] New to updated list as of June 25, 2020 Hypertension Cohort Study [1, 2, 49, 50, 51, 91, 93]
Case Series [92]
Systematic Review [52]
Meta Analyses [3, 4, 53, 94] New to updated list as of June 25, 2020 Pregnancy Systematic Review [54]
Case Control Study [55]
Case Series [56, 57, 58, 59]
Cohort Study [60, 61, 62] On previous version of list Use of corticosteroids or other immunosuppressive medications Case Series [67, 68, 69]
Cohort Study [70, 71] On previous version of list Limited Evidence Bone marrow transplantation Review [72] On previous version of list HIV Case Series [73, 74]
Cohort Study [109, 110, 111, 112] On previous version of list Immune deficiencies Case Series [75]
Systematic Review [76] On previous version of list Inherited metabolic disorders Cohort Study [47, 77] New to updated list as of June 25, 2020; specific to pediatric populations at this time Liver disease Meta-Analysis [78]
Cohort  Study [79, 80]
Literature Review [81] On previous version of list Neurologic conditions Cross-Sectional Study [82]
Cohort Study [41, 49, 77] New to updated list as of June 25, 2020; specific to pediatric populations at this time Other chronic lung diseases Meta-Analysis [4]
Case Series [17]
Cohort Study [14, 83] On previous version of list Overweight (BMI > 25 kg/m2, but < 30 kg/m2) Cohort Study [96, 106]
Case Series [97] Previously unlisted Pediatrics Systematic Review [84, 85]
Cross-Sectional Study [82, 86, 107]
Cohort Study [77, 87, 88, 103, 108, 113] New to updated list as of July 17, 2020 Thalassemia Case Series [89]
Cross-Sectional Study [90] On previous version of list Type 1 diabetes mellitus Case Series [11]
Cohort Study [36, 37]
Meta-Analysis [38]
Cross-Sectional Study [114] On previous version of list

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